Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot. Wound healing is an innate mechanism of action that works reliably most of the time. Diabetic foot problems, such as ulcerations, infections and gangrene are the most common cause of hospitalization among diabetic patients. Routine ulcer care, treatment of infections, amputations, and hospitalizations cost billions of dollars every year and place a tremendous burden on the health care system. Successful treatment of diabetic foot ulcers consists of addressing these three basic issues; Debridement, offloading, and infection control.